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KMID : 0608520060120010049
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Korean Journal of Oriental Medicine
2006 Volume.12 No. 1 p.49 ~ p.57
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A monitoring for the establishment of microbial limit of herbal medicine (Ⅰ)
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Lee Ju-Hyun
Jeon Won-kyung
Ko Byoung-Seob
Chun Jin-Mi
Lee A-eong
Kim Ho-kyoung
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Abstract
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Objectives: This study has attempted to establish an organized system for the microbiological quality of raw materials which are important factors in preparing the standard for microbial limits.
Methods: This study has first set up microbial contamination limit test, total aerobic microbial count and total fungi count, in accordance with testing method of the Korea Pharmacopeia 8th edition in order to establish an inspection standard for microbial contamination.
Results: The microbial contamination of 18 items that are highly prone to contamination by three regions (Seoul, Daejeon, Gyeongsangbuk-do). As a results, Morus alba Linne and Rehmannia glutinosa Liboschitz var. purpurea Makino showed as high contaminated by WHO’s Microbial Contamination Limit standard. In case of Yukjin medicine in the Theory of Herb Medicinal Properties, total bacterial contamination rate showed as 17.7%, total fungal contamination rate showed as 41.2% and total aerobic microbial count and total fungi count on Ephedra sinica Stapf, Pinellia ternata Breitenbach, Evodia officinalis Dode showed as high measured. The microbial contamination rate of raw materials which make up Yukmijihwanghwan were mostly high therefore the total aerobic microbial count was measured as high in case of Yukmijihwanghwan, the characteristics about microbial contamination strain is to be researched.
Conclusions: By combining the basic data and experimental results related to microbial contamination of herb medicine, the most ideal storage standards for herb medicine has been attempted to be presented.
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KEYWORD
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microbial contamination limit test, herb medicine, Yukjin medicine, Yukmijihwanghwan
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